Cosmetics are incredible in demand since historical time till day. Lipstick formulations are most widely used to enhance the beauty of lips and to add glamor's touch to the makeup. It is difficult to apply lipsticks to the dried, chafed, chapped, cracked lips with sores and lesions. In such cases, one can use medicated lipsticks for the purpose of curing topical infections and beautification of lips. With this aim and objectives, an attempt was made to formulate medicated lipstick by using kokum butter as natural excipients that substituted synthetic ingredients like isopropyl myristate, lanolin, cetyl alcohol, and castor oil. Clotrimazole was selected a model drug for the local action on lips. In vitro evaluation was done on cellophane membrane, and the data suggested that the drug remained on the membrane only and did not diffuse through the membrane in diffusion studies for 4 h. After 4 h, drug release was observed. Thus, clotrimazole can remain topically on lips for 4h without showing any systemic effects. The lipsticks were evaluated for their organoleptic properties such as spreading, covering property, hardness, shine, and gloss and found to be satisfactory product to give attractive beauty with therapeutic effect on the diseased lips. Thus, the medicated lipsticks with the natural ingredients like kokum butter can serve as economical and effective cosmoseutical product.
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